abstract：:Cardiovascular disease is a chronic disorder which is usually already at an advanced stage when the first symptoms develop. The fact that the initial clinical presentation can be lethal or highly incapacitating emphasizes the need for primary and secondary prevention. It is estimated that the ratio of patients with go...

journal_title：Medicina clinica

authors： González-Juanatey JR,Mostaza JM,Lobos JM,Abarca B,Llisterri JL,Baron-Esquivias G,Galve E,Lidón RM,Garcia-Moll FX,Sánchez PL,Suárez C,Millán J,Pallares V,Alemán JJ,Egocheaga I

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The association of an exaggerated systolic blood pressure increase with exercise (EBPIE) with cardiovascular events remains controversial. Our aim was to determine the possible association of an EBPIE with survival and risk of serious cardiac events in patients with hypertension and known or su...

journal_title：Medicina clinica

authors： Bouzas-Mosquera C,Bouzas-Mosquera A,Peteiro J

更新日期：2017-01-20 00:00:00

abstract：INTRODUCTION:The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with renal involvement are associated with high morbi-mortality. In this study we analyse if the prognosis of these diseases have improved in recent years, and which factors influence the outcomes. MATERIAL AND METHODS:Retrospective sin...

journal_title：Medicina clinica

authors： Caravaca-Fontán F,Yerovi E,Delgado-Yagu E M,Galeano C,Pampa-Saico S,Tenorio MT,Liaño F

更新日期：2017-01-06 00:00:00

abstract：:Most patients with type 2 diabetes have excess adiposity. There is wide consensus that adequate treatment of type 2 diabetes requires a simultaneous approach to overweight/obesity and the remaining cardiovascular risk factors. Non-pharmacological interventions (diet, exercise) represent the cornerstone of the treatmen...

journal_title：Medicina clinica

authors： Gómez Huelgas R

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evo...

journal_title：Medicina clinica

authors： Yébenes-Ramírez M,Serrano J,Martínez-Losada C,Sánchez-García J

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease. Our objective was to evaluate subclinical atherosclerosis in OSA patients and the effect of continuous positive airway pressure (CPAP) treatment on carotid intima-media thickness (cIMT). PATIENTS AND...

journal_title：Medicina clinica

authors： Català R,Ferré R,Cabré A,Girona J,Porto M,Texidó A,Masana L

更新日期：2016-07-01 00:00:00

abstract：FOUNDATIONS AND AIM:The aim of this study is to analyze the CHADS2 score as a marker of the risk of mortality in hypertensive patients, with and without the presence of atrial fibrillation. METHODS:We included 1,003 hypertensive patients≥65 years. Risk factors, and CHADS2 score were recorded among other factors, as we...

journal_title：Medicina clinica

authors： Castilla E,Morillas P,Gómez M,Ahumada M,Monteagudo M,Fácila L,Pallares V

更新日期：2016-06-03 00:00:00

abstract：:Since Perrinaud in 2006 first described three patients with hemorrhagic bullae in relation to the use of heparins, numerous cases have been published. Currently, this entity has been established as a clearly defined pathology. We review all reported cases, diagnostic features and features that differentiate it from ot...

journal_title：Medicina clinica

authors： Castellanos-González M,Velasco-Rodríguez D,Mancebo Plaza AB

更新日期：2016-05-06 00:00:00

abstract：:It is the aim of this manuscript to take into account the peculiarities and specific characteristics of elderly patients with chronic ischaemic heart disease from a multidisciplinary perspective, with the participation of the Spanish Society of Cardiology (sections of Geriatric Cardiology and Ischaemic Heart Disease/A...

journal_title：Medicina clinica

authors： Martínez-Sellés M,Gómez Huelgas R,Abu-Assi E,Calderón A,Vidán MT

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:This study investigated the burden (incidence, mortality and serotype distribution) of pneumococcal pneumonia among older adults in the region of Tarragona (Spain). METHODS:Population-based cohort study involving 27,204 individuals ≥60 years in Tarragonès county (Southern Catalonia), who were prospectively ...

journal_title：Medicina clinica

authors： Vila-Corcoles A,Ansa X,Ochoa-Gondar O,Satue E,de Diego C,Rodriguez-Blanco T,EPIVAC Research Team.

更新日期：2016-03-04 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Primary biliary cirrhosis (PBC) is associated to any systemic autoimmune disease (SAD), in particular systemic sclerosis (SSc). To investigate the prevalence of SAD in a cohort of patients with PBC, specifically the prevalence of SSc and its clinical subtypes, and determining the clinical and ...

journal_title：Medicina clinica

authors： Marí-Alfonso B,Amengual-Guedan MJ,Vergara-Gómez M,Simeón-Aznar CP,Fonollosa-Plà V,Jove-Buxeda E,Oliva-Morera J,Tolosa-Vilella C

更新日期：2016-01-01 00:00:00

abstract：:Tuberculosis remains one of the communicable diseases that cause increased morbidity and mortality worldwide. With an incidence rate of 13,04 per 100,000 population, Spain ranks third among the most affected European countries. These data show a tendency to decrease meaning that it may go unnoticed with the potential ...

journal_title：Medicina clinica

authors： Casas I,Dominguez J,Rodríguez S,Matllo J,Altet N,SEPAR.,GEIM.,SEIMC.,AEEMT.,Programa de Prevención y control de la Tuberculosis (Catalan Public Health Agency).

更新日期：2015-12-21 00:00:00

abstract：:Podoconiosis, mossy foot or endemic non-filarial elephantiasis, is a geochemical disease that causes lower limb lymphedema; it is directly related to walking barefoot over soils of volcanic origin, in areas with a high pluviometric annual index. It has a specific geographical distribution, affecting around 5% populati...

journal_title：Medicina clinica

authors： Prieto-Pérez L,Soriano Cea JJ,Górgolas Hernández-Mora M

更新日期：2015-11-20 00:00:00

abstract：BACKGROUND AND OBJECTIVE:High levels of daily physical activity have been shown to be linked to decreased functional impairment in peripheral artery disease (PAD) patients and positively related to the ankle brachial index (ABI) in subjects without PAD. The aim of this study was to examine the relationship between leis...

journal_title：Medicina clinica

authors： Ruiz Comellas A,Pera G,Baena Díez JM,Heras A,Alzamora Sas MT,Forés Raurell R,Torán Monserrat P,Mundet Tudurí X

更新日期：2015-11-20 00:00:00

abstract：INTRODUCTION:Recently diagnosis of latent tuberculosis infection (LTBI) can be made using the tuberculin skin test (TST) or by techniques known as interferon-γ release assays (IGRAS), being QuantiFERON(®)-TB Gold In-Tube (QF-G-IT) the most used. The IGRAS avoid some drawbacks of the TST, especially cross-reaction with ...

journal_title：Medicina clinica

authors： Martinez Lacasa X,Canals Font R,Jaen Manzanera A,Cuchi Burgos E,Lite Lite J

更新日期：2015-11-20 00:00:00

abstract：:In February 2014, the autonomous government in Catalonia, the Generalitat de Catalunya, approved the Catalan Public Health System Interdepartmental Plan (PINSAP, as per the Catalan acronym), responsible for the strategy in Catalonia for Health in All Policies, as recommended by the WHO and other international institut...

journal_title：Medicina clinica

authors： Mateu i Serra A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Gaucher disease is an inherited disorder caused by deficit of acid β-glucocerebrosidase, responsible for the degradation of glucosylceramide to ceramide and glucose. Although the disorder is primarily hematologic, bone is the second most commonly affected structure. Cathepsin K (CATK) is an enz...

journal_title：Medicina clinica

authors： Bobillo Lobato J,Durán Parejo P,Núñez Vázquez RJ,Jiménez Jiménez LM

更新日期：2015-10-05 00:00:00

abstract：:Systemic lupus erythematosus is an autoimmune disease associated with an aberrant production of autoantibodies by self-reactive B lymphocytes. The study of the phenotypic characteristics of B lymphocytes and the identification of their surface receptors such as BAFF-R, TACI and BCMA, which are responsible of their sur...

journal_title：Medicina clinica

authors： Valor L,López-Longo FJ

更新日期：2015-09-07 00:00:00

abstract：:Amyotrophic neuralgia is an uncommon neuropathy characterized by severe unilateral shoulder pain. Isolated or concomitant involvement of other peripheral motor nerves depending on the brachial plexus such as phrenic or laryngeal nerves is unusual(1). Its etiology is unknown, yet several explanatory factors have been p...

journal_title：Medicina clinica

authors： García García Mdel C,Hernández Borge J,Antona Rodríguez MJ,Pires Gonçalves P,García García G

更新日期：2015-09-07 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Twin and family studies support large genetic influences on variability in body mass index (BMI), with heritability estimates ranging from 47% to over 90%. Our objective was to study the relative contributions of genetics and environment to BMI, evaluating sex differences, in an adolescent twin...

journal_title：Medicina clinica

authors： Iranzo-Tatay C,Gimeno-Clemente N,Livianos-Aldana L,Rojo-Moreno L

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Obesity is characterized by a generalized increase of adipose tissue, high production of adipocytokines and presence of oxidative systemic stress. The objective of this study was to evaluate the changes generated in the oxidative stress and anthropometric parameters in obese subjects by the pre...

journal_title：Medicina clinica

authors： Gutiérrez L,García JR,Rincón Mde J,Ceballos GM,Olivares IM

更新日期：2015-07-06 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The optimal treatment of aggressive non-Hodgkin lymphoma (NHL) in elderly patients remains controversial. We aimed to evaluate the impact of age and use of anthracyclines. PATIENTS AND METHOD:Retrospective analysis of patients with aggressive NHL aged over 70 years old. RESULTS:One hundred an...

journal_title：Medicina clinica

authors： Ancochea Á,Salar A,García-Pallarols F,Gimeno E,Fernández-Rodriguez C,Sánchez-González B

更新日期：2015-06-22 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We analyzed baseline and kinetic characteristics of lipid metabolism during the first month of bitherapy in patients with chronic hepatitis C genotype 1 (CHC-1). PATIENTS AND METHODS:A longitudinal, prospective study including 99 naïve CHC-1 patients with liver biopsy who were treated with bit...

journal_title：Medicina clinica

authors： Jiménez Macías FM,Barrero Alor F,Casado Monge PG,Ramos Lora M,Pujol de la Llave E,Ruíz-Frutos C

更新日期：2015-06-22 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We aimed to test a new telerehabilitation device for stress urinary incontinence (SUI) in order to make an initial assessment of its effectiveness. PATIENTS AND METHOD:Randomized, controlled pilot study. INTERVENTION:experimental group (10 patients): pelvic floor muscle training, device train...

journal_title：Medicina clinica

authors： Carrión Pérez F,Rodríguez Moreno MS,Carnerero Córdoba L,Romero Garrido MC,Quintana Tirado L,García Montes I

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The ankle-brachial index allows for the detection of subclinical cardiovascular disease and risk, by diagnosing peripheral arterial disease and arterial calcification. Asymptomatic hypertensive men, between 45-55 years and with the suspicion of low risk, could be an important population group t...

journal_title：Medicina clinica

authors： Oliveras V,Martín-Baranera M,Gracia M,Del Val JL,Plans M,Pujol-Moix N

更新日期：2015-05-21 00:00:00

abstract：BASIS AND OBJECTIVE:Hepatic steatosis, also known as non-alcoholic fatty liver (NAFL), is the most frequent liver disease in obese children. Due to an increase in infantile obesity, it is experiencing a significant increment in incidence. Our objetives are: Estimate the prevalence of NAFL in children with excess weight...

journal_title：Medicina clinica

authors： Guijarro de Armas MG,Monereo Megías S,Navea Aguilera C,Merino Viveros M,Vega Piñero MB

更新日期：2015-01-20 00:00:00

abstract：OBJECTIVES:To describe 11 patients with cardiofaciocutaneous syndrome (CFC) and compare them with 130 patients with other RAS-MAPK syndromes (111 Noonan syndrome patients [NS] and 19 patients with LEOPARD syndrome). PATIENTS AND METHODS:Clinical data from patients submitted for genetic analysis were collected. Bidirec...

journal_title：Medicina clinica

authors： Carcavilla A,García-Miñaúr S,Pérez-Aytés A,Vendrell T,Pinto I,Guillén-Navarro E,González-Meneses A,Aoki Y,Grinberg D,Ezquieta B

更新日期：2015-01-20 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Endoscopy is the gold standard to assess disease severity in inflammatory bowel disease, although it is an invasive procedure. Clinical activity and biological markers have been routinely used to determine disease activity in a non-invasive manner. The aim of this study was to determine concor...

journal_title：Medicina clinica

authors： Miranda García P,Chaparro M,Gisbert JP

更新日期：2015-01-06 00:00:00

abstract：:Pulmonary thromboembolism (PE) is a common cause of morbidity and mortality in patients with cancer. Having cancer is an independent risk factor for death in the general series of patients with PE and is included as a variable in the prognostic scales of acute symptomatic PE. This fact limits the discriminatory power ...

journal_title：Medicina clinica

authors： Font C,Carmona-Bayonas A,Plasencia JM,Calvo-Temprano D,Sánchez M,Jiménez-Fonseca P,Beato C,Biosca M,Vicente V,Otero R,en representación de los Investigadores del Proyecto EPIPHANY.

更新日期：2015-01-01 00:00:00

abstract：:The dual antiplatelet therapy with acetylsalicylic acid and clopidogrel has been the mainstay of both acute and chronic phase coronary artery disease, reducing importantly the risk of adverse events. Despite a correct compliance, a non-negligible rate of adverse events still happens. New compounds, with improved prope...

journal_title：Medicina clinica

authors： Tello-Montoliu A,Jover E,Valdés M

更新日期：2014-12-09 00:00:00

abstract：:Multiple sclerosis occurs in genetically susceptible individuals, in whom an unknown environmental factor triggers an immune response, giving rise to a chronic and disabling autoimmune disease. Currently, significant progress is being made in our knowledge of the frequency and distribution of multiple sclerosis and it...

journal_title：Medicina clinica

authors： Fernández Ó

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:To study the factors associated with prolonged hospitalization in patients admitted for acute heart failure (AHF) in Spanish short-stay units (SSUs). PATIENTS AND METHODS:This was a multicentre, multipurpose cohort study with prospective follow-up including all patients admitted for AHF in the...

journal_title：Medicina clinica

authors： Martín-Sánchez FJ,Carbajosa V,Llorens P,Herrero P,Jacob J,Pérez-Dura MJ,Alonso H,Torres Murillo JM,Garrido M,López-Grima ML,Piñera P,Epelde F,Alquezar A,Fernández C,Miró O,en representación del grupo ICA-SEMES.

更新日期：2014-09-15 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion. Moreover slows gastric emptying -reducing postprandial glycemic excursions-, reduces body weight, systolic blood pressure a...

journal_title：Medicina clinica

authors： Jódar E

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between g...

journal_title：Medicina clinica

authors： Jiménez-Massa AE,Alonso-Sardón M,Menacho-Miguel JA,Mirón-Canelo JA,González-Sarmiento R

更新日期：2014-08-04 00:00:00

abstract：:The aging of the population and changes in family and social structures have led to increasing care needs for elderly persons following an acute disease or accident, with consequent concerns regarding costs and sustainability within the public health system. The main objective of postacute care (PAC) is to restore the...

journal_title：Medicina clinica

authors： Admetlla Falgueras M,Fusté Sugrañes J

更新日期：2014-07-07 00:00:00

abstract：:Since its inception in 2006, the Alliance for Patient Safety in Catalonia has played a major role in promoting and shaping a series of projects related to the strategy of the Ministry of Health, Social Services and Equality, for improving patient safety. One such project was the creation of functional units or committ...

journal_title：Medicina clinica

authors： Saura RM,Moreno P,Vallejo P,Oliva G,Alava F,Esquerra M,Davins J,Vallès R,Bañeres J

更新日期：2014-07-01 00:00:00

abstract：:Number needed to treat has been recommended as an easy way to transmit results from a trial, especially controlled clinical trials. Most articles estimate it from a 2×2 table, as the inverse of the absolute risk reduction. However, some limitations have been pointed out: The interpretation is not as easy as claimed, c...

journal_title：Medicina clinica

authors： Gómez-Acebo I,Dierssen-Sotos T,Llorca J

更新日期：2014-05-20 00:00:00

abstract：:Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent disease in the general population, associated with an increase in the cardiovascular morbimortality. A basic and/or standardized otolaryngologic exploration could help us to detect the structural abnormalities that alter the upper airway collapsibility a...

journal_title：Medicina clinica

authors： Ferré A,Vila J,Arcalís N

更新日期：2014-04-07 00:00:00

abstract：:Reduction in the risk of cardiovascular complications through modification of lipids is currently focused on lowering low density lipoproteins-cholesterol, with statins being the preferred drugs. New agents, under research, such as antibodies neutralizing PCSK9, will have a special place for the management of patients...

journal_title：Medicina clinica

authors： Mostaza JM,Lahoz C

更新日期：2014-04-07 00:00:00

abstract：:The use of physical and pharmacological restraint is controversial but is currently accepted as inevitable. It is indicated for controlling behavioral disorders and psychomotor agitation that put patients and third parties at risk. Its indication should be medical, and we should opt for the least restrictive measure. ...

journal_title：Medicina clinica

authors： Gómez-Durán EL,Guija JA,Ortega-Monasterio L

更新日期：2014-03-01 00:00:00